In this inaugural lecture, Professor Ama de-Graft Aikins discusses the psychology of chronic disease risk, experience and care in Africa. She makes a case for why the problem of NCDs needs to be examined through a psychological lens. She draws on her independent and collaborative work on diabetes representations and experiences among Ghanaians in Ghana and Europe, and the broader African and global health literature, to highlight the complex multi-level context of chronic disease risk, experience and care. She presents a synthesis of the evidence through the concepts of physical ills and ideological ills, arguing that both are interconnected and, as a result, must be addressed through interdisciplinary approaches. She concludes by offering practical solutions for reducing chronic disease risk and improving the quality of long-term experience and care in Ghana, using examples from countries that have implemented successful NCD interventions.