The process of exchange and acculturation with Western culture in Vietnam from the 17th century took place strongly. Especially when Alexandre de Rhodes (1591-1660) came to Vietnam to spread Catholicism and contributed to the creation of modern Vietnamese words and Latinized Vietnamese words, Vietnamese culture has made profound changes. The Latinized Vietnamese word appears as a means of activation, has spread very quickly the new religious consciousness (Catholic). On the one hand, it promotes Vietnamese thinking and language increasingly integrated with Western civilization, absorbing positive values. On the other hand, it led the way for Catholic development, along with the French imperialists' invasion of Vietnam. In this book, author Bui Kha has presented a number of documents that have not been widely disseminated in Vietnam, along with quite reasonable arguments based on resources at libraries of Europe and the US on the issue of Vietnamese alphabet and missionaries.