Since early 2020, the COVID-19 pandemic has exacerbated the human lives of every conner across the world. Cambodia and the Southeast Asian region are no exception. This Foundation's particular publication is specifically looking into the impact of the pandemic in Cambodia and across the region in detail through the diplomatic, economic and social contexts. Southeast Asia remains vulnerable in many aspects. Although the respective countries have taken consecutive, far-reaching measures to contain the spread of the virus and to cure the infected, more precaution guidelines are still needed. It is hence more timely and important than ever to assess and try to shed a new perspective on the enduring struggles now and the prospective challenges in the future. The discussion surrounding the Covid-19 pandemic has been widely conducted on various platforms in every corner of the globe in the form of op-ed, short commentary and articles, video-conferences and virtual panel discussions alike. Never-theless, it fell short of scientific research and constructive analysis in a more concrete, in-depth format, e.g., a book compilation, for future reference and extended outlook.