A regional network of researchers across tertiary institutions in Southern Africa focused their work on gender and sexuality within the higher education context. Their work included answering questions about some of the silences and gaps in knowledge production concerning sexual and gender minorities; politics of research and funding that are implicated in considering what is knowledgeable in the field of sexual and gender research; what impediments influence how institutions embark on transformative agendas and priorities affecting sexual and gender diverse persons; what may experience and everyday encounters of those positioned as ‘other’ inform us about institutional transformation. This book brings together research and on-going reflections on the relationship between sexual and gender identities; individual and social strategies of social interaction within these spaces; nuances of teaching and learning in the classroom for change, community engagement, relation with self and others, institutional protection of sexual and gender integrity through policy. The various chapters in the book address and document different shifts, experiences and challenges faced by sexual and gender minorities within higher education contexts across the region. The contributors of this book draw from their research, teaching and reflexive practice as educators, allies, members of LGBTI+ communities, researchers and activists to think through the meanings of transformation in higher education: Meanings that include an awareness of what it means to confront narrative and discursive constructs as ‘other’ because of one’s perceived and real sexual and gendered embodiment.