This book offers an essential guide to the concepts of knowledge and civilisation in Islam. It presents a bird's-eye view from the Islamic perspective, serving as a reference rather than an encyclopedia. While it does not cover every topic related to knowledge and civilisation, it focuses on answering key questions such as the Islamic perspective on knowledge and civilisation, the relationship between knowledge, information and data, the formation of civilisation, the role of urban settlements, and the importance of knowledge in shaping civilisation. The book is divided into two main sections, one on knowledge and the other on civilisation, and begins by examining the concept of reality and the interplay between epistemology, ontology and axiology.